Quantification of circulating endothelilial cells (CECs) as a predictor of response to chemotherapy with platinum and pemetrexed in patients with nonsquamous non-small cell lung carcinoma

Autor:	Remei Blanco, Silvia Catot, Oscar Juan, Alfredo Sanchez-Hernandez, Jose Garcia Sanchez, G. Esquerdo, Sonia Maciá, Francisco Aparisi, Francisco Garcia-Pinon, Jose Vidal, J. Garde
Rok vydání:	2012
Předmět:	Oncology Cancer Research medicine.medical_specialty Chemotherapy Lung business.industry medicine.medical_treatment Cancer medicine.disease medicine.anatomical_structure Pemetrexed Internal medicine medicine Carcinoma In patient Non small cell business medicine.drug
Zdroj:	Journal of Clinical Oncology. 30:e18053-e18053
ISSN:	1527-7755 0732-183X
Popis:	e18053 Background: CECs play an important role in tumor neovascularisation and may have prognostic value in cancer patients (pts). The objective of this study is to assess the quantification of CECs as a predictor of response to chemotherapy (CT) in non-squamous NSCLC. Methods: 10ml of blood was obtained prior to the first, second and third cycle of CT in pts treated with platinum plus Pemetrexed. The quantification of CECs was undertaken using CellSearch technology in a central laboratory. The basal levels and the evolution of CECs was correlated with response to treatment according to RECIST criteria after 3 cycles of CT using analysis of variance (ANOVA). Results: Between July 2010 and June 2011 67 pts were included: 43 pts (64.2%) received CDDP/PEM and 24 (35.8%) received CBDCA/PEM. Median age: 60 years (range 40-82), 46 male (68,7%). Nine (13,4%) PS 0; 46 (68,7%) PS 1; 11 (16,4%) PS 2; 1 (1,5%) PS 3. Range of basal CECs: 8 - 1171 cel (median of 85 cel). CECs prior to cycle 2: median of 100 cel (range: 10-1388). CECs prior to ciclo 3: median of 94,5 cel (range: 5-1857). Response after 3 cycles was: 25 PR (36%), 17 SD (25%) and 16 PD (23%) and 11 NE (16%). In the analysis of variance, no significant relationship between the basal CEC count and response was found (p-value=0,831). Decrease >50% between the 1st and 2nd cycle is correlated significantly with progression disease (p=0.026). Conclusions: In this homogeneous group of patients with NSCLC there is no correlation between response to treatment and basal levels of CECs. The decrease in CEC numbers after the first cycle could be a negative predictive factor. The correlation between the variations of CECs with PFS and OS will be presented during the conference.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b2617f5d68ac8bcc4b38ae07af4b7794 https://doi.org/10.1200/jco.2012.30.15_suppl.e18053 Zobrazit plný text záznamu