Polymer-assisted solution-phase (PASP) library synthesis of α-ketoamides

Autor:	John J. Parlow, Tom Dice, South Michael S
Rok vydání:	2000
Předmět:	chemistry.chemical_classification Chemistry Periodinane Bioengineering Sequence (biology) Polymer Applied Microbiology and Biotechnology Solution phase Chemical synthesis chemistry.chemical_compound Amide Reagent Organic chemistry Amine gas treating Biotechnology
Zdroj:	Biotechnology and Bioengineering. 71:51-57
ISSN:	1097-0290 0006-3592
Popis:	A parallel solution-phase library synthesis of α-ketoamides is described. The two-step library synthesis is accomplished using polymer-assisted solution-phase (PASP) synthesis techniques. This high-yielding, multi-step sequence utilizes sequestering resins for the removal of reactants, reactant by-products, and tagged reagents. The first step of the library synthesis utilizes PASP resins to mediate the amide coupling of an α-hydroxy acid with an amine. The second step uses PASP resins for the periodinane oxidation of the α-hydroxy acid to an α-ketoamide leaving highly pure products after simple filtration and evaporation. © 2000 John Wiley & Sons, Inc. Biotechnol Bioeng (Comb Chem) 71:51–57, 2000.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b25ab70bda65efdc354a915311189037 https://doi.org/10.1002/(sici)1097-0290(200024)71:1<51::aid-bit8>3.0.co Zobrazit plný text záznamu Plný text