The chemical synthesis of the RP and SP diastereomers of thymidyl(3′-5′)thymidyl 0,0-phosphorothioate

Autor:	Bogdan Uznanski, Wojciech Niewiarowski, Wojciech J. Stec
Rok vydání:	1982
Předmět:	Stereospecificity Chemistry Stereochemistry Organic Chemistry Drug Discovery Diastereomer Absolute configuration Biochemistry Chemical synthesis
Zdroj:	Tetrahedron Letters. 23:4289-4292
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(00)88727-4
Popis:	The synthesis and separation of diastereomere of protected thymidyl(3′–5′)thymidyl 0,0-phosphoranilidate (4) allowed to obtain in the stereospecific manner title compounds 5, whose absolute configuration at P atom was assigned enzymatically. TP(S)T diastereomers (5) were obtained independently via “phosphite” procedure.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b257c347a7e2eaf823cda7a12f7dad73 https://doi.org/10.1016/s0040-4039(00)88727-4 Zobrazit plný text záznamu