| Autor: |
Swee W Leong, Saskia Bos, James L Lordan, Arun Nair, Andrew J Fisher, Gerard Meachery |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
BMJ Open Respiratory Research. 10:e001387 |
| ISSN: |
2052-4439 |
| DOI: |
10.1136/bmjresp-2022-001387 |
| Popis: |
BackgroundInterstitial lung disease (ILD) has emerged as the most common indication for lung transplantation globally. However, post-transplant survival varies depending on the underlying disease phenotype and comorbidities. This study aimed to describe the demographics, disease classification, outcomes and factors associated with post-transplant survival in a large single-centre cohort.MethodsData were retrospectively assessed for 284 recipients who underwent lung transplantation for ILD in our centre between 1987 and 2020. Patient characteristics and outcomes were stratified by three eras: 1987–2000, 2001–2010 and 2011–2020.ResultsMedian patients’ age at time of transplantation was significantly higher in the most recent decade (56 (51–61) years, pConclusionIn patients transplanted for end-stage ILD, older age and fibrotic non-specific interstitial pneumonia were associated with poorer post-transplant survival. The benefit of bilateral over single lung transplantation diminished with increasing age, suggesting that single lung transplantation might still be a feasible option in older candidates. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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