Acidosis láctica por metformina: reporte de caso
| Autor: | Jesús Salvador Sánchez-Díaz, Enrique Monares-Zepeda, Rosalba Carolina García-Méndez, Enrique Antonio Martínez-Rodríguez, Oscar Torres-Aguilar, Gerardo Rivera-Solís, Susana Patricia Díaz-Gutiérrez, María Verónica Calyeca-Sánchez, Juan Marcelo Huanca-Pacaje, Jorge Samuel Cortés-Román, Karla Gabriela Peniche-Moguel, Eusebio Pin-Gutiérrez |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Critical Care and Intensive Care Medicine 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine 030212 general & internal medicine Renal replacement therapy Intensive care medicine Sodium bicarbonate business.industry food and beverages 030208 emergency & critical care medicine Metabolic acidosis medicine.disease Metformin Lactic acid Anesthesiology and Pain Medicine chemistry Anesthesia Shock (circulatory) Lactic acidosis medicine.symptom Severe lactic acidosis business medicine.drug |
| Zdroj: | Revista Colombiana de Anestesiología. 45:353-359 |
| ISSN: | 0120-3347 |
| DOI: | 10.1016/j.rca.2017.07.009 |
| Popis: | Lactic acidosis is defined as the presence of pH 2.0 mmol/L and PaCO2 < 42 mmHg. However, the definition of severe lactic acidosis is controversial. The primary cause of severe lactic acidosis is shock. Although rare, metformin-related lactic acidosis is associated with a mortality as high as 50%. The treatment for metabolic acidosis, including lactic acidosis, may be specific or general, using sodium bicarbonate, trihydroxyaminomethane, carbicarb or continuous haemodiafiltration. The successful treatment of lactic acidosis depends on the control of the aetiological source. Intermittent or continuous renal replacement therapy is perfectly justified, shock being the argument for deciding which modality to use. We report a case of a male patient presenting with metformin poisoning as a result of attempted suicide, who developed lactic acidosis and multiple organ failure. The critical success factor was treatment with continuous haemodiafiltration. |
| Databáze: | OpenAIRE |
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