Enhanced skeletal growth of sheep heterozygous for an inactivated fibroblast growth factor receptor 31
| Autor: | K. L. Rodrigue, Logan B. Smith, Roberto Daniel Sainz, Anita M. Oberbauer, Martin R. Dally |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
musculoskeletal diseases
Bone growth congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Long bone Context (language use) General Medicine Fibroblast growth factor receptor 3 Biology Chondrocyte stomatognathic diseases medicine.anatomical_structure Endocrinology Growth factor receptor Internal medicine Genetics medicine Animal Science and Zoology Fibroblast Endochondral ossification Food Science |
| Zdroj: | Journal of Animal Science. 84:2942-2949 |
| ISSN: | 1525-3163 0021-8812 |
| DOI: | 10.2527/jas.2006-255 |
| Popis: | Normal fibroblast growth factor receptor 3 (FGFR3) acts as a negative bone growth regulator by restricting chondrocyte proliferation and endochondral bone elongation. In sheep, a heritable mutation that inactivates FGFR3 produces skeletal overgrowth when homozygous, this condition is commonly referred to as spider lamb syndrome (SLS). We hypothesized that sheep heterozygous for the inactivated FGFR3 mutation (FGFR3(SLS/+)) would exhibit enhanced long bone growth and greater frame size; additionally, the isolated effects of increased bone growth would translate into greater BW and larger LM area relative to normal lambs at harvest. The current study investigated bone length and LM area of FGFR3(SLS/+) sheep at maturity and during growth. At maturity, FGFR3(SLS/+) ewes exhibited a larger frame size and longer bones than normal FGFR3(+/+) ewes (P 0.2). A similar LM area produced in the context of a greater frame size and skeletal length produces a greater muscle volume, thereby potentially increasing meat yield. The results of this study suggest that FGFR3(SLS/+) animals exhibit a relaxation of the normal inhibition of chondrocyte proliferation, resulting in an increase in the overall frame size. The sheep industry could utilize the naturally occurring genetic mutation in FGFR3 to potentially increase meat yields with enhanced skeletal growth as an alternative to exogenous growth promotants. |
| Databáze: | OpenAIRE |
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