Spezifischer Wirkstoff transport durch Rezeptorinternalisierung

Autor:	Annette G. Beck-Sickinger, Verena M. Ahrens, Stefanie Babilon, Kerstin Burkert
Rok vydání:	2013
Předmět:	Ligand Chemistry Pharmacology toxicology Pharmacology Receptor Molecular Biology hormones hormone substitutes and hormone antagonists Biotechnology G protein-coupled receptor Cell biology
Zdroj:	BIOspektrum. 19:499-501
ISSN:	1868-6249 0947-0867
DOI:	10.1007/s12268-013-0345-6
Popis:	G-protein coupled receptors (GPCRs) are involved in many physiological and pathophysiological roles. Many important drugs act on GPCRs, either by blocking them (antagonists) or by mimicking the natural ligand (agonists). As GPCRs have been shown to internalize a new concept is currently investigated: application of agonistic ligands fused to drugs to allow selective uptake into specific cells. This has been proven for selective uptake into tumour cells but may be expanded to other systems that selectively express GPCRs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b23e73e40f33be1bb533096fd1a04cf6 https://doi.org/10.1007/s12268-013-0345-6 Zobrazit plný text záznamu Full text from SpringerLink