Meroterpenoids produced by Pseudocosmospora sp. Bm-1-1 isolated from Acanthus ebracteatus Vahl
| Autor: | Nanang Rudianto Ariefta, Ari Widiyantoro, Junpei Abe, Yoshihito Shiono, Tetsuya Murayama, Rikhsan Kurniatuhadi, Desi Harneti, Takuya Koseki, Abdul Malik, Naoaki Kurisawa, Suwardi Annas, Takuma Suzuki, Rani Maharani, Tomoki Nakamura, Unang Supratman, Takako Aboshi, Ken-ich Kimura |
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| Rok vydání: | 2019 |
| Předmět: |
Acanthus ebracteatus
Hl60 cells biology 010405 organic chemistry Stereochemistry Saccharomyces cerevisiae Ethyl acetate Plant Science Fractionation biology.organism_classification 01 natural sciences Biochemistry 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry Cytotoxic T cell Spectral analysis Agronomy and Crop Science IC50 Biotechnology |
| Zdroj: | Phytochemistry Letters. 31:85-91 |
| ISSN: | 1874-3900 |
| Popis: | Fractionation of ethyl acetate extract obtained by culturing the endophytic fungus Pseudocosmospora sp. Bm-1-1 resulted in the isolation of four new meroterpenoids, cosmosporin A (1), 6-carboxy-cosmosporin A (2), rel-(6aS,10aR)-Δ9-tetrahydrocannabiorcolic acid B (3) and 8′-hydroxy-cannabiorcichromenic acid (4), in addition to four known compounds 5–8. Structures were elucidated by spectral analysis, as well as by directly comparing the spectral data of new compounds with those of known compounds. Cannabiorcichromenic acid (5), decarboxy-cannabiorcichromenic acid (6), and rel-(6aS,10aR)-decarboxy-Δ9-tetrahydrocannabiorcolic acid B (8) restored growth of a Saccharomyces cerevisiae mutant strain involving Ca2+ signal transduction. Furthermore, compounds 3 and 8 had cytotoxic activity against HL60 cells (3: IC50 = 24.1 μM and 8: IC50 1.6 μM). |
| Databáze: | OpenAIRE |
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