A collaborative, double-blind randomized study of cetiedil citrate in sickle cell crisis
| Autor: | Vipul N. Mankad, Lawrence M. Lewkow, Lee A. Berkowitz, Eugene P. Orringer, Ram K. Chillar, Charles M. Peterson, Lennette J. Benjamin, Ananda S. Prasad |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
medicine.medical_specialty
Dose Hemoglobin SC Disease business.industry Cetiedil citrate Immunology Cell Biology Hematology Placebo Biochemistry Surgery law.invention Double blind chemistry.chemical_compound Hemoglobin A Randomized controlled trial chemistry law Anesthesia medicine Cetiedil business |
| Zdroj: | Blood. 67:1442-1447 |
| ISSN: | 1528-0020 0006-4971 |
| DOI: | 10.1182/blood.v67.5.1442.1442 |
| Popis: | We have recently completed a double-blind, placebo-controlled, noncrossover study, the goal of which was to determine whether cetiedil citrate (cetiedil) could affect the course of vaso-occlusive crises in sickle cell disease. Patients, who presented to the emergency room at least 4 but no more than 24 hours after the onset of a painful vasoocclusive crisis severe enough to require hospitalization, were considered candidates for the study. Each patient received either placebo or cetiedil at one of the following three dosages: 0.2, 0.3, or 0.4 mg/kg body weight. The assigned drug dosage was given as a 30 minute intravenous infusion every 8 hours for 4 consecutive days. A total of 67 patients was enrolled in the study. Cetiedil, at its highest dosage (0.4 mg/kg body weight), was found to be significantly superior to placebo both in reducing the number of painful sites present on all 4 treatment days and in shortening the total time in crisis. No serious adverse reactions were observed during the course of the study. We conclude that cetiedil, given at a dosage of 0.4 mg/kg body weight, is therapeutically advantageous for sickle cell crisis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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