Features of the morphofunctional state of the endocrine part of the pancreas during the development of experimental diabetes in the presence of regulatory peptides
| Autor: | T. A. Shubina, A. M. Ul’yanov |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
endocrine system
medicine.medical_specialty endocrine system diseases Peptide General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Diabetes mellitus Internal medicine Alloxan Endocrine system Medicine General Environmental Science chemistry.chemical_classification geography geography.geographical_feature_category business.industry Pancreatic islets medicine.disease Islet Endocrinology medicine.anatomical_structure chemistry Nasal administration General Agricultural and Biological Sciences business Pancreas |
| Zdroj: | Moscow University Biological Sciences Bulletin. 64:63-65 |
| ISSN: | 1934-791X 0096-3925 |
| DOI: | 10.3103/s0096392509020023 |
| Popis: | The multiple 7-day intranasal introduction of PGArg and GPArg peptides at a dose of 1 mg per kg body weight before the injection of the diabetogenic dose of alloxan provided the maintenance of normoglycemia in rats. The similar introduction of PGPArg peptide did not provide any protection against the development of diabetes mellitus. The quantity of pancreatic islets in the animals from this group remained quite comparable to the norm, but the total number of cells per islet was below the norm, as well as in the control group. The GPArg peptide showed the best results as a preventive anti-diabetic agent. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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