| Autor: |
Abdolhossien Madani, Abdolreza Sotoodeh Jahromi, Mohammad Shojaei, Fatemeh Mehdizadeh, Saeedeh Erfanian |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
American Journal of Immunology. 10:10-13 |
| ISSN: |
1553-619X |
| Popis: |
Immune system and inflamation is widely known to play a key role in the development and progression of cardiovascular diseases. Anti-Phospholipid (aPL) an tibodies may act in the induction of immunological response leading to the development of Acute Myocardial Infarction (AMI). Anti-Phosphatidyl Inositole (PI) Antibody (Ab) has been seen in various diseases inc luding rheumatoid arthritis, systemic lupus erythem atosus and anti-phospholipid antibody syndrome. Although there are a few studies on the association of some autoantibodies with AMI, more epidemiological data are required to confirm their significance as indep endent risk factors in cardiovascular diseases. Moreover, the data on the relationship of autoantibodies with traditional risk factors of AMI is rare. The study of anti-PI A b in AMI may lead to understand of etiology of isch emic heart disease. This study was conducted to determin e whether prevalence of anti-PI Abs, in patients wh o had AMI and to analyze their association with tradition al cardiovascular risk factors. The prevalence of a nti-PI IgG and IgM in a well characterized group of patients w ith AMI as a case group and in age and sex matched healthy subjects as control group. Sera from the ca se and the control groups were tested to evaluate t he presence of IgG and IgM isotypes to anti-PI by ELIS A method. The prevalence of anti-PI IgG and also Ig M in the case group resulted significantly higher than i n the control group with AMI (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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