High resolution CBV assessment with PEAK-EPI: k-t-undersampling and reconstruction in echo planar imaging
| Autor: | Bernd Jung, Rebecca Ramb, Irina Mader, Maxim Zaitsev, Jürgen Hennig |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Physics
medicine.diagnostic_test media_common.quotation_subject Magnetic resonance imaging Blood volume Magnetic resonance angiography 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Nuclear magnetic resonance Flip angle Undersampling medicine Contrast (vision) Radiology Nuclear Medicine and imaging Cerebral perfusion pressure Image resolution 030217 neurology & neurosurgery media_common |
| Zdroj: | Magnetic Resonance in Medicine. 77:2153-2166 |
| ISSN: | 0740-3194 |
| Popis: | PURPOSE Achieving higher spatial resolution and improved brain coverage while mitigating in-plane susceptibility artifacts in the assessment of perfusion parameters, such as cerebral blood volume, in echo planar imaging (EPI)-based dynamic susceptibility contrast weighted cerebral perfusion measurements. METHODS PEAK-EPI, an EPI sequence with interleaved readout trajectories and three different strategies for autocalibration-signal acquisition (inplace, dynamic extra and extra) is presented. Performance of each approach is analyzed in vivo based on flip angle variation induced dynamics, assessing temporal fidelity, temporal SNR and g-factors. All approaches are compared with conventional GRAPPA reconstructions. PEAK-EPI with inplace autocalibration-signal at R = 5 is then compared with the standard clinical EPI protocol in six patients, using two half-dose dynamic susceptibility contrast weighted cerebral perfusion measurements per subject. RESULTS PEAK-EPI acquisition facilitates a substantial increase of spatial resolution at a higher number of slices per TR and provides improved SNR compared to conventional GRAPPA. High dependency of the resulting reconstruction quality on the type of autocalibration-signal acquisition is observed. PEAK-EPI with inplace autocalibration-signal achieves high temporal fidelity and initial feasibility is shown. CONCLUSION The obtained high resolution cerebral blood volume maps reveal more detailed information than in corresponding standard EPI measurements and facilitate detailed delineation of tumorous tissue. Magn Reson Med 77:2153-2166, 2017. © 2016 International Society for Magnetic Resonance in Medicine. |
| Databáze: | OpenAIRE |
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