| Autor: |
Hans-Uirich Demuth, Jorn Schmidt, Michael Wermann, Fred Rosche |
| Rok vydání: |
1996 |
| Předmět: |
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| Zdroj: |
Protein & Peptide Letters. 3:385-392 |
| ISSN: |
0929-8665 |
| DOI: |
10.2174/092986650306221101113916 |
| Popis: |
Abstract: Z-Phe-Pro-(isonicotinic acid methylester) methylketone is a highly potent inhibitor (Ki*= 18 nM) of prolyl endopeptidase from Flavobacterium meningosepticum. It acts as a slow-binding inhibitor and decomposes to compounds still possessing inhibitory activity.The pathway of decomposition was analyzed qualitatively and quantitatively applying MALDI-TOF mass spectrometry. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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