Naphthalene derivatives and halogenate quinoline from the coral-derived fungus Trichoderma harzianum (XS-20090075) through OSMAC approach
| Autor: | Jia-Yin Yu, Ying Xu, Chang-Yun Wang, Ting Shi, Dong-Lin Zhao, Yue Zhou |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pharmacology
Natural product biology 010405 organic chemistry Stereochemistry Organic Chemistry Quinoline Absolute configuration Pharmaceutical Science Trichoderma harzianum General Medicine Fungus biology.organism_classification 01 natural sciences 0104 chemical sciences Analytical Chemistry 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Complementary and alternative medicine chemistry Trichoderma Drug Discovery Molecular Medicine Naphthalene Derivative Naphthalene |
| Zdroj: | Journal of Asian Natural Products Research. 23:250-257 |
| ISSN: | 1477-2213 1028-6020 |
| Popis: | OSMAC approach was performed on the soft coral-derived fungus Trichoderma harzianum (XS-20090075) leading to the significant changes of its secondary metabolites by using two different cultures. A new naphthalene derivative, trichoharzin B (1) and a new natural product, methyl-trichoharzin (2) were isolated by using rice medium. Whereas, a new natural product, ethyl 2-bromo-4-chloroquinoline-3-carboxylate (9) was obtained by using Czapek's medium. Their structures were established by extensive spectroscopic investigation. The absolute configuration of 5 was determined by single-crystal X-ray diffraction. Compound 9 was the first halogenate quinoline derivative isolated from the genus of Trichoderma. |
| Databáze: | OpenAIRE |
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