Quantitative near-infrared spectroscopy discriminates between mitochondrial myopathies and normal muscle
| Autor: | B.G.M. van Engelen, Willy N.J.M. Colier, M.C.P. van Beekvelt, Ron A. Wevers |
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| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_specialty
Pathology business.industry Maximum voluntary contraction technology industry and agriculture Isometric exercise equipment and supplies medicine.disease surgical procedures operative Neurology Mitochondrial myopathy Normal muscle Internal medicine Forearm blood flow medicine Cardiology Handgrip exercise In patient Neurology (clinical) Chronic progressive external ophthalmoplegia business neoplasms |
| Zdroj: | Annals of Neurology. 46:667-670 |
| ISSN: | 1531-8249 0364-5134 |
| DOI: | 10.1002/1531-8249(199910)46:4<667::aid-ana19>3.0.co;2-d |
| Popis: | Five patients with chronic progressive external ophthalmoplegia (CPEO) and 27 healthy controls were examined by near-infrared spectroscopy (NIRS) for the noninvasive and direct quantitative measurement of muscle oxygen consumption and forearm blood flow. NIRS measurements were obtained in rest and during static isometric handgrip exercise at 10% of the maximum voluntary contraction (MVC) force. A significantly decreased oxygen consumption at rest as well as during exercise was found in patients with CPEO. Our results suggest that NIRS is able to discriminate between CPEO patients and healthy controls, which makes NIRS a valuable tool in the diagnostic workup of patients suspected to have a mitochondrial myopathy. |
| Databáze: | OpenAIRE |
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