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Summary Background Chronic disease can have physical and psychological effects which affect social functioning. These effects can be better understood from the perspective of parent and child by the use of health-related quality of life (HRQL) measures. Various HRQL measures are now available, of which generic health measures have been the most widely used. These permit comparison between different diseases and also the normal population. Objectives To cross-validate a new generic HRQL proxy measure for children, the Children's Life Quality Index© (CLQI), with an established speciality-specific dermatological questionnaire, the Children's Dermatology Life Quality Index© (CDLQI), in a group of children with chronic skin diseases. The impairment of HRQL in the same group of children with skin disease was then compared with that associated with other common chronic childhood diseases using the CLQI. Methods The CDLQI was completed by 379 children aged 5–16 years with skin disease of more than 6 months’ duration. Their parents (n = 379) and parents of 161 children aged 5–16 years with other chronic diseases were also asked to complete a proxy measure, the CLQI. Results Using linear regression analysis, the CLQI and the CDLQI scores showed a strong linear association (rs = 0·72, P |
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