Darunavir concentrations exceed the protein-corrected EC50 for wild-type HIV in the semen of HIV-1-infected men
| Autor: | Stephen Taylor, Laura Else, David Back, Gerry Gilleran, Amanda Berry, Ngozi E. Dufty, Erasmus J Smit, Ashini Jayasuriya |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Immunology Semen Drug resistance Biology medicine.disease biology.organism_classification Infectious Diseases Endocrinology Acquired immunodeficiency syndrome (AIDS) Internal medicine Blood plasma Lentivirus medicine Immunology and Allergy Ingestion Sida Darunavir medicine.drug |
| Zdroj: | AIDS. 24:2583-2587 |
| ISSN: | 0269-9370 |
| DOI: | 10.1097/qad.0b013e32833ead18 |
| Popis: | Variable antiretroviral drug penetration into the genital tract may contribute to the differential evolution of HIV-1 and the emergence of drug resistance. We compared concentrations of darunavir in 34 time-matched blood plasma and seminal plasma samples from 18 HIV-1 positive men. Darunavir in seminal plasma were approximately 10-20% of that achieved in blood at matched time points postdrug ingestion. All seminal plasma darunavir were above the protein-corrected EC₅₀ values for wild-type HIV-1. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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