2H-benzimidazoles (isobenzimidazoles). Part 6. Sulfur derivatives

Autor:	Brian Iddon, Hans Suschitzky, Justine C. Hazelton, Ley H. Woolley
Rok vydání:	1992
Předmět:	Reaction conditions Bicyclic molecule chemistry Derivative (finance) Nucleophilic substitution Organic chemistry chemistry.chemical_element Solvent effects Sodium benzenesulfinate Sulfur
Zdroj:	Journal of the Chemical Society, Perkin Transactions 1. :685
ISSN:	1364-5463 0300-922X
DOI:	10.1039/p19920000685
Popis:	The products obtained by treating 2H-benzimidazole-2-spirocyclohexane 1 or its 5-chloro derivative 9 with various thiols (PrSNa, ButSNa, PhSNa, pyridine-2-thiol, or pyrimidine-2-thiol) depend on the reaction conditions. Monosubstitution is possible and any number of alkylthio groups can be introduced up to four.5-Phenylsulfonyl-, 18 and 5-nitro-2H-benzimidazole-2-spirocyclohexane 10 react with pyridine-2-thiol or pyrimidine-2-thiol in position-4 whilst the 5-(pyridin-2-ylthio) derivative 16 reacts with sodium benzenesulfinate in position-6. In all cases the products isolated were the 1,3-dihydrocompounds 26, 38, 39 or 21, respectively.
Databáze:	OpenAIRE
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