Ultrasmall natural peptides self-assemble to strong temperature-resistant helical fibers in scaffolds suitable for tissue engineering
| Autor: | Rensheng Deng, Yon Jin Chuah, Yihua Loo, Charlotte A. E. Hauser, Jackie Y. Ying, Hwan T. Hee, Archana Mishra |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
chemistry.chemical_classification
Materials science Biomedical Engineering Self assemble Pharmaceutical Science New materials Bioengineering Peptide Nanotechnology Biocompatible material Amino acid Extracellular matrix chemistry Tissue engineering Self-healing hydrogels General Materials Science Biotechnology |
| Zdroj: | Nano Today. 6:232-239 |
| ISSN: | 1748-0132 |
| DOI: | 10.1016/j.nantod.2011.05.001 |
| Popis: | Summary A new class of systematically designed ultrasmall (tri- to heptamer) peptides presents the smallest natural, non-aromatic structures that self-assemble in water to hydrogels. The peptide motif consists of an aliphatic amino acid tail of decreasing hydrophobicity capped by a polar head. The fibrous scaffolds assemble from nanostructured aggregates to condensed three-dimensional (3D) meshes, entrapping up to 99.9% water and resembling collagen fibers in the extracellular matrix. The resulting hydrogels are biocompatible, heat resistant up to 90 °C and demonstrate tunable, high mechanical strength. Given their facile and cost-effective synthesis, these new materials would be attractive for applications ranging from injectable medical therapies to tissue-engineered scaffolds. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect