Pattern of Cervical Cytology and High Risk Human Papillomavirus Strains in Non HIV Positive Women Presenting for Cervical Cancer Screening in Port Harcourt, Nigeria
| Autor: | E. O. Oranu, T. K. Nyengidiki |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cervical cancer medicine.medical_specialty business.industry Obstetrics Prevalence medicine.disease 03 medical and health sciences Squamous intraepithelial lesion 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis Management of Technology and Innovation Cytology Genotype Chi-square test Medicine business Prospective cohort study Genotyping |
| Zdroj: | Journal of Biosciences and Medicines. :68-76 |
| ISSN: | 2327-509X 2327-5081 |
| DOI: | 10.4236/jbm.2018.66005 |
| Popis: | Background: The high risk human papilloma virus (hrHPV) is largely associated with cervical cancer with identifiable dysplastic changes on cytology. The use of cervical cancer screening strategies has largely improved the general outcome of cervical malignancies globally. Objective: To compare cervical cytological features against human papilloma virus genotypes in non HIV positive patients presenting for cervical cancer screening in UPTH. Method: A cross sectional prospective study of 82 non HIV positive women who presented for cervical cancer screening at the University of Port Harcourt Teaching hospital. A prestructured questionnaire was used to obtain socio demographic information. Cytobrush extracts of cervical samples were subjected to cytology and human papilloma virus DNA genotyping using real-time polymerase chain reaction. The information obtained was analyzed using SSPP version 20 and results presented as frequency tables, percentages and tested for significance using student t-test and chi square with p value < 0.05 at 95% confidence interval. Results: The mean age of the women was 36.61 ± 7.75 with an age range of 22 - 58 years. The prevalence of HrHPV was 4.88%. Twenty-two of the respondent have abnormal cytological pattern. While the 4 cases of HrHPV positivity were of normal cytological pattern and occurred in respondents that were in their reproductive age, the 22 that showed abnormal cervical cytology were mainly of low grade squamous intraepithelial lesion (LGSIL). There was no case of high grade squamous cell intraepithelial lesion (HGSIL). Conclusion: HrHPV prevalence rate of 4.88% occurring in low socioeconomic class patients. All the cervical abnormalies were of LGSIL, hence the risk of transformation into cervical cancer is equally low. There may be no correlation between hrHPV and cervical cytology in low risk patients. |
| Databáze: | OpenAIRE |
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