ChemInform Abstract: Novel Hypoglycemic Dihydropyridones Serendipitously Discovered from O- versus C-Alkylation in the Synthesis of VMAT2 Antagonists

Autor:	Donald W. Landry, Masanori Ichise, Anthony J. Raffo, Shi-Xian Deng, Paul L. Harris, Yuli Xie
Rok vydání:	2009
Předmět:	Vesicular monoamine transporter Chemistry Diabetes mellitus medicine Structure–activity relationship General Medicine Pharmacology Alkylation medicine.disease
Zdroj:	ChemInform. 40
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200905147
Popis:	Vesicular monoamine transporter type 2 (VMAT2) is a newly emerging target for both diagnostic and therapeutic applications in diabetes mellitus. In pursuit of novel VMAT2 antagonists, we identified a potent hypoglycemic agent with a novel dihydropyridone scaffold. Several analogs were designed and synthesized. A preliminary structure activity relationship (SAR) showed that the dihydropyridone scaffold is required for the activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b1f4a9e95e2a71626fb4b80cfc12af79 https://doi.org/10.1002/chin.200905147 Zobrazit plný text záznamu Plný text