Demoor's Active Substance of the Heart
| Autor: | C. H. McDonald, A. C. McDonald |
|---|---|
| Rok vydání: | 1933 |
| Předmět: | |
| Zdroj: | Experimental Biology and Medicine. 30:786-788 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-30-6674 |
| Popis: | Demoor1, 2 has described a humoral regulatory substance elaborated by the nodal tissue of the heart which has the property of conferring rhythmicity upon the aperiodic beat of an isolated left auricle. His theory is based chiefly upon the observation that the right auricle of the rabbit or guinea pig, excised and dropped into a Ringer-Locke solution, soon assumes a regular rhythm; the left auricle, however, gives only aperiodic, jerky beats in this solution. If now, the solution in which the right auricle has been active for a while is poured over the left auricle, the latter gives rhythmical beats. Demoor has prepared both saline and alcoholic extracts of the right auricle of the rabbit which were able to confer periodicity upon the isolated left auricle of the rabbit. He has named this unknown substance the “active substance” of the heart. The writers have been able to confirm his observations.All solutions used in the experiments were made from Baker's analyzed chemicals, recrystallized. The Ringer-Loc... |
| Databáze: | OpenAIRE |
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