A novel colorimetric strategy for sensitive and rapid sensing of ascorbic acid using cobalt oxyhydroxide nanoflakes and 3,3′,5,5′-tetramethylbenzidine
| Autor: | Ya-Hui Du, Zhongming Huang, Yalei Hu, Danyang Ji, Lin Zhang, Fei Yu, Hong-Min Meng, Zhaohui Li, Jianjun Li |
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| Rok vydání: | 2018 |
| Předmět: |
Detection limit
010401 analytical chemistry Metals and Alloys Analytical chemistry 02 engineering and technology 3 3' 5 5'-Tetramethylbenzidine 021001 nanoscience & nanotechnology Condensed Matter Physics Serum samples Ascorbic acid 01 natural sciences 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Highly sensitive Absorbance chemistry.chemical_compound Cobalt oxyhydroxide chemistry Materials Chemistry Electrical and Electronic Engineering 0210 nano-technology Colorimetry Instrumentation Nuclear chemistry |
| Zdroj: | Sensors and Actuators B: Chemical. 256:512-519 |
| ISSN: | 0925-4005 |
| DOI: | 10.1016/j.snb.2017.10.070 |
| Popis: | In this work, cobalt oxyhydroxide nanoflakes (CoOOH nanoflakes) were reported to possess a high oxidizability toward TMB for the first time and based on which we have developed a new strategy for qualitative and quantitative detection of ascorbic acid (AA). In our design, CoOOH nanoflakes can directly oxidize 3,3′,5,5′-tetramethylbenzidine (TMB) to oxTMB with an obvious blue color emerging, and AA can selectively inhibit the oxidation of TMB to oxTMB by resolving CoOOH nanoflakes to Co2+, resulting in a decrease in the absorbance of oxTMB and bleaching of blue color. As such, the concentration of AA could be identified very easily by UV–vis spectroscopy and bare eyes. Under optimal conditions, this sensing platform showed a highly sensitive response to AA with a detection limit of 142 nM and a short assay time of 5 min. This assay was also successfully used to quantify AA in human serum samples and practical food samples. Importantly, using this fabricated sensing strategy, we have further developed a paper-based strip sensor for AA detection with satisfactory results, showing its great potential for point of care applications. |
| Databáze: | OpenAIRE |
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