Identifizierung von Überträgern der chronischseptischen Granulomatose*: Bestimmung der Superoxid-Radikal-Bildung

Autor:	M. Rister
Rok vydání:	2008
Předmět:	chemistry.chemical_compound Chronic granulomatous disease medicine.anatomical_structure chemistry Phagocytosis Superoxide radical Nbt test medicine General Medicine Granulocyte medicine.disease Hydrogen peroxide Molecular biology
Zdroj:	DMW - Deutsche Medizinische Wochenschrift. 105:1814-1816
ISSN:	1439-4413 0012-0472
DOI:	10.1055/s-2008-1070965
Popis:	Chronic granulomatous disease is caused by an X chromosome-linked granulocyte function defect whereby the superoxide radical (O2-) and hydrogen peroxide are not formed during phagocytosis. In the course of the investigation of the family of a boy with chronic granulomatosis disease carriers could not be established using the NBT test. Only determination of O2- formation by granulocytes during phagocytosis led to identification of disease carriers. This may possibly represent a means for prenatal diagnosis.
Databáze:	OpenAIRE
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