Synthesis and characterization of original N-meso chiral substituted diarylporphyrins

Autor:	Anh Tuan Lormier, Zahra Abada, Bernardin Akagah, Bruno Figadère, Laurent Ferrié
Rok vydání:	2012
Předmět:	Steric effects Chiral auxiliary Atropisomer Stereochemistry Organic Chemistry chemistry.chemical_element Nuclear magnetic resonance spectroscopy Biochemistry Porphyrin chemistry.chemical_compound chemistry Drug Discovery Polymer chemistry Moiety Amination Palladium
Zdroj:	Tetrahedron Letters. 53:6961-6964
ISSN:	0040-4039
Popis:	A first palladium catalyzed cross-coupling amination with chiral auxiliaries at the two meso positions of diarylporphyrins was reported. We noticed that, the non-metallation of porphyrins and steric hinderance of the chiral auxiliary play an essential role to the effectiveness of this cross coupling-reaction. Here, when two methyl pyroglutamates were added, the reaction leads to atropisomers and their behaviors were investigated by NMR spectroscopy. Finally, functionalizations of these chiral porphyrins were performed onto the pyrroglutamate moiety to give new original chiral porphyrins.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b1d6c1721380765eaa7b3831bc4db4f4 https://doi.org/10.1016/j.tetlet.2012.10.041 Zobrazit plný text záznamu Full Text from ScienceDirect