The Intriguing Reactivity of Functionalized β-Amino Alcohols with Glyoxal: Application to a New Expedient Enantioselective Synthesis of trans-6-Alkylpipecolic Acids

Autor:	Sébastien Comesse, Catherine Kadouri-Puchot, Claude Agami
Rok vydání:	2002
Předmět:	chemistry.chemical_classification Stereochemistry Organic Chemistry Enantioselective synthesis Chemical synthesis chemistry.chemical_compound Enantiopure drug chemistry Moiety Organic chemistry Glyoxal Vinylsilane Lactone Pipecolic acid
Zdroj:	The Journal of Organic Chemistry. 67:2424-2428
ISSN:	1520-6904 0022-3263
Popis:	New β-amino alcohols possessing a vinylsilane moiety were reacted with glyoxal to produce lactones that were transformed in three steps in enantiopure pipecolic acid derivatives. The key step was a...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b1d6344fb224885f0f1b8db001751ad1 https://doi.org/10.1021/jo010780+ Zobrazit plný text záznamu