Synthesis of mangiferin derivatives as protein tyrosine phosphatase 1B inhibitors
| Autor: | Shichong Yu, Chao-Mei Liu, Qingjie Zhao, Yan Song, Ming-juan Wang, Jun Zhang, Wansheng Chen, Hongli Liao, Honggang Hu, Ling-zhi Cai, Qiuye Wu |
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| Rok vydání: | 2007 |
| Předmět: |
Plant Science
General Chemistry Type 2 diabetes Protein tyrosine phosphatase medicine.disease Inhibitory postsynaptic potential Protein Tyrosine Phosphatase 1B General Biochemistry Genetics and Molecular Biology Negative regulator chemistry.chemical_compound chemistry Biochemistry Glucoside Xanthone medicine Mangiferin hormones hormone substitutes and hormone antagonists |
| Zdroj: | Chemistry of Natural Compounds. 43:663-666 |
| ISSN: | 1573-8388 0009-3130 |
| DOI: | 10.1007/s10600-007-0223-x |
| Popis: | Protein tyrosine phosphatase 1B (PTP1B) has received much attention due to its pivotal role in type 2 diabetes and obesity as a negative regulator of the insulin signaling pathway. Mangiferin, a xanthone glucoside, has been reported to possess significant antidiabetic activity. In the present study, a series of mangiferin derivatives was synthesized and evaluated for their PTP1B inhibitory activity. Some of the screened compounds displayed good PTP1B inhibitory activity. |
| Databáze: | OpenAIRE |
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