| Autor: |
Shankar Arumugam, Archana Prabahar, Saranya Jayapalan |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Fungal Biology ISBN: 9783030530761 |
| DOI: |
10.1007/978-3-030-53077-8_3 |
| Popis: |
Several fungal infections occur in human body and cause various health issues and also create critical impacts to our health. Among these fungal infections, Aspergillus infections are emerging as life-threatening yet underappreciated and underdeveloped as compared to other microbial infections. Aspergillosis is a serious threat to human life and requires more attention in terms of diagnosis and treatment. Siderophores play an important role in fungal virulence and iron acquisition mechanisms and also helps in the process of treatment and therapy of such fungal infections. In this chapter, we discussed various infections caused by Aspergillus species and their virulence in different stages of the disease. The two major Aspergillus pathogens A. fumigatus and A. nidulans were taken for the study, and their siderophoric system involved in biosynthetic pathway and the role of siderophores involved in Aspergillus species has been discussed. From this review, we suggest that fungal siderophore biosynthetic pathway might represent promising therapeutic targets for the treatment of aspergillosis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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