Improved synthesis of tertiary propargyl alcohols by the Favorskii reaction of alkyl aryl (hetaryl) ketones with acetylene

Autor:	Boris A. Trofimov, Nadezhda I. Protsuk, A. I. Mikhaleva, E. Yu. Shmidt, Ivan A. Bidusenko
Rok vydání:	2013
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Atmospheric pressure Acetylene chemistry Yield (chemistry) Aryl Organic Chemistry Propargyl Organic chemistry Favorskii reaction Laboratory scale Alkyl
Zdroj:	Russian Journal of Organic Chemistry. 49:8-11
ISSN:	1608-3393 1070-4280
DOI:	10.1134/s1070428013010028
Popis:	Alkyl aryl (hetaryl) ketones react with acetylene under atmospheric pressure in the superbasic system KOH-EtOH-H2O-DMSO at 10–15°C (2 h) to give the corresponding tertiary propargyl alcohols in up to 91% yield. The procedure requires no large excess of KOH and low-boiling inflammable solvents, produces few wastes, and is safe and convenient on the laboratory scale; there are no limitations for its large-scale application.
Databáze:	OpenAIRE
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