Effects of selective serotonin reuptake inhibitors on auditory processing
| Autor: | R. G. Daniloff, L. Pennartz, D. M. Daly, Kamakshi V. Gopal |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Fluoxetine
medicine.medical_specialty Acoustics and Ultrasonics business.industry media_common.quotation_subject Fluvoxamine Audiology Serotonin reuptake Serotonergic Lethargy Arts and Humanities (miscellaneous) otorhinolaryngologic diseases medicine Cholinergic business Acoustic reflex medicine.drug Vigilance (psychology) media_common |
| Zdroj: | The Journal of the Acoustical Society of America. 105:1346-1347 |
| ISSN: | 0001-4966 |
| Popis: | In mammalian auditory systems, serotonergic and cholinergic systems modulate inhibition of GABA‐ergic interneurons. Auditory processing has been evaluated in a patient who suffered withdrawn depression, lethargy, hypersensitivity to touch/pressure, light, and sound (but not taste/smell), and difficulty understanding speech. Treatment with fluvoxamine and fluoxetine, selective serotonin reuptake inhibitors, reversibly alleviated complaints. A sibling is similarly afflicted. Testing while medicated and at least 15 days after voluntary withdrawal (unmedicated; symptomatic without depression) revealed pure tone, SRT, word discrimination scores, tympanograms, and acoustic reflex thresholds within normal limits. Medicated SCAN‐A results were normal; unmedicated results were disordered. Unmedicated, both otoacoustic emissions and ABR waves I, III, and V, were significantly larger, bilaterally. Central processing and vigilance were evaluated with sets of sparse acoustic stimuli. While medicated, responses to stim... |
| Databáze: | OpenAIRE |
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