The effect of substrate fibrinolysis on the fibroblast growth
| Autor: | Hajime Yasuda, Mikio Takeuchi, Mamoru Ueyama, Shun Hirakawa, Toshio Asada, Tsutomu Urayama, Masahiro Tomono |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
biology
Chemistry Cell growth Plasmin medicine.medical_treatment technology industry and agriculture macromolecular substances General Medicine Fibrin Cell biology Fibronectin medicine.anatomical_structure Immunology Fibrinolysis medicine biology.protein Fibroblast Cell adhesion Wound healing medicine.drug |
| Zdroj: | Blood & Vessel. 17:78-80 |
| ISSN: | 1884-2372 0386-9717 |
| DOI: | 10.2491/jjsth1970.17.78 |
| Popis: | Fibrin adhesion substrate and factor-XIII plays an important role in fibroblast growth during wound healing process. The effect of fibrinolysis on the cell growth was investigated to propose that fibrinolysis resistance by factor-XIII instead of fibronectin crosslinking was required to keep cell adhesion and growth. 3T6 cells in the medium supplemented with normal FCS were not proliferated on the non-crosslinked fibrin with fibrinolysis probably induced by the cell-derived activator, but well grown on the crosslinked fibrin. 3T6 cells in the medium with plasminogen-free serum were well grown even on the non-crosslinked fibrin without possibility of fibronectin crosslinking. BHK and S-180 cells were well grown in every cases regardless of the crosslinking and fibrinolysis. Plasmin pretreatment of fibrin, however, did not influence on the growth of any cells. The results indicated that not degradated substrate surface but some released products in the medium might have the effect on the cell growth, although the susceptibility depends on cell lines. |
| Databáze: | OpenAIRE |
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