Assessment of the active-site requirements of lanosterol 14.alpha.-demethylase: evaluation of novel substrate analogs as competitive inhibitors

Autor:	Stephen F. Tuck, James V. Silverton, Cecil H. Robinson
Rok vydání:	1991
Předmět:	chemistry.chemical_classification biology Chemistry Stereochemistry medicine.medical_treatment Organic Chemistry Substrate (chemistry) Active site Cytochrome P450 Biological activity Steroid Biochemistry Triterpene Enzyme inhibitor Lanosterol 14 alpha-demethylase biology.protein medicine
Zdroj:	The Journal of Organic Chemistry. 56:1260-1266
ISSN:	1520-6904 0022-3263
Popis:	A partir d'3β-acetate de lanost-7-ene-3β,30-diol, synthese de 14α-allyl, 14α-propyl, 14α-vinyl, 14α-ethyl-4,4-dimethyl-5α-cholest-7-en-3β-ol et de 30-thiiran-2-yl, 30-oxiran-2-yl-lanost-7-en-3β-ol. Etude de leur activite inhibitrice de la lanosterol 14α-demethylase a cytochrome P450
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b1bebfd62fa7064f9e319e0aab69c924 https://doi.org/10.1021/jo00003a059 Zobrazit plný text záznamu