Synthetic neovibsanes and their ability to induce neuronal differentiation in PC12 cells

Autor:	C. Catharina Müller, P.-J. Chen Annette, Helen M. Cooper, Craig M. Williams
Rok vydání:	2010
Předmět:	Natural product biology Neurite Stereochemistry Organic Chemistry Neuronal differentiation Neovibsanin B Total synthesis Biological activity Biochemistry Chemical synthesis Cell biology chemistry.chemical_compound chemistry Drug Discovery biology.protein Neurotrophin
Zdroj:	Tetrahedron. 66:6842-6850
ISSN:	0040-4020
DOI:	10.1016/j.tet.2010.06.056
Popis:	A series of neovibsanin A and B derivatives and lower homologues were synthesized to study their neurotrophic ability with PC12 cells. 4,5-Bis-epi-neovibsanin A displayed prominent ability to induce neurite outgrowth compared to control cultures. Herein we describe the total synthesis of 4,5-bis-epi-neovibsanin A and B as well as comparing the biological activity of several neovibsane derivatives.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b1bb99bf11e4c8fe6f9a6bf18b08f437 https://doi.org/10.1016/j.tet.2010.06.056 Zobrazit plný text záznamu Full Text from ScienceDirect