| Autor: |
Umut Kocabaş, Işıl Ergin, Veysel Yavuz, Selda Murat, İbrahim Özdemir, Ömer Genç, Cihan Altın, Haşim Tüner, Bengisu Keskin Meriç, Ali Çoner, Elif İlkay Yüce, Bedrettin Boyraz, Onur Aslan, Ahmet Dal, Taner Şen, Ersin İbişoğlu, Aslan Erdoğan, Mehmet Özgeyik, Mevlüt Demir, Ziya Gökalp Bilgel, Büşra Güvendi Şengör, Örsan Deniz Urgun, Mustafa Doğduş, Deniz Dilan Naki Tekin, Sinem Çakal, Sercan Çayırlı, Arda Güler, Dilay Karabulut, Onur Dalgıç, Osman Uzman, Bektaş Murat, Şeyda Şahin, Umut Karabulut, Tarık Kıvrak, Muharrem Said Coşgun, Ferhat Özyurtlu, Mehmet Kaplan, Emre Özçalık |
| Rok vydání: |
2022 |
| DOI: |
10.21203/rs.3.rs-1828621/v1 |
| Popis: |
Purpose: Inappropriate dosing of direct oral anticoagulants is associated with an increased risk of stroke, systemic embolism, major bleeding, cardiovascular hospitalization, and death in patients with atrial fibrillation. The main goal of the study was to determine the prevalence and associated factors of inappropriate dosing of direct oral anticoagulants in real-life settings.Methods: This study was a multicenter, cross-sectional, observational study that included 2,004 patients with atrial fibrillation. The study population was recruited from 41 cardiology outpatient clinics between January and May 2021. The main criteria for inappropriate direct oral anticoagulant dosing were defined according to the recommendations of the European Heart Rhythm Association. Results: The median age of the study population was 72 years and 58% were women. Nine hundred and eighty-seven patients were prescribed rivaroxaban, 658 apixaban, 239 edoxaban, and 120 dabigatran. A total of 498 patients (24.9%) did not receive the appropriate dose of direct oral anticoagulants. In a logistic regression model, advanced age, presence of chronic kidney disease, presence of permanent atrial fibrillation, prescription of reduced doses of direct oral anticoagulants, prescription of edoxaban treatment, concomitant use of amiodarone treatment, and non-use of statin treatment were significantly associated with potentially inappropriate dosing of direct oral anticoagulants. Conclusion: The study demonstrated that the prevalence of inappropriate direct oral anticoagulant dosing according to the European Heart Rhythm Association recommendations was 24.9% in patients with atrial fibrillation. Several demographic and clinical factors were associated with the inappropriate prescription of direct oral anticoagulants. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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