Lung transplantation survival in silicosis
| Autor: | Sara Silva, Fernando Martelo, Ricardo Marques Coelho, Nídia Caires, João Cardoso, Ana Santos, Ivan Bravio, José Fragata, João Reis, Nicole Murinello, Luísa Semedo, Tiago Sá, Vânia Caldeira |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Lung business.industry medicine.medical_treatment Primary Graft Dysfunction Perioperative respiratory system medicine.disease Gastroenterology Idiopathic pulmonary fibrosis FEV1/FVC ratio medicine.anatomical_structure Silicosis Internal medicine Medicine Lung transplantation business Hypersensitivity pneumonitis |
| Zdroj: | Occupational and Environmental Health. |
| DOI: | 10.1183/1393003.congress-2017.oa482 |
| Popis: | Introduction: Silicosis is a less frequent disease with indication for lung transplantion (LT) known for being a challenging surgery with difficult pneumectomy and surgical complications. Objectives: Comparative analysis of survival and complications after LT for silicosis and other interstitial diseases. Methods: Retrospective analysis of patients (pts) who underwent single LT (SLT) between 2010 and 2015. Mann-Whitney and chi-squared tests were used. Results: Were evaluated 43 pts: 5 silicosis and 38 other interstitial lung diseases (ILD) -hypersensitivity pneumonitis (45%, n=17), idiopathic pulmonary fibrosis (21%, n=8) and others (34%, n=13). All the pts with silicosis were male, average age of 48y, mean FVC of 2273mL (57%) and FEV1 of 1808mL (57%). The ILD group (n=38) had 53% females (n=20), mean age of 53y, FVC of 1582mL (48%) and FEV1 of 1326mL (48%). For the ILD group the 3-month survival was 95% and at 1 year 85% while the pts with silicosis had a 1-year survival of 100%. There was an increased use of blood components (80% vs 53%), ECMO support (40% vs 18%) and an increase average ischemic time (415 vs 352min) in silicosis. Also, there was an increase in primary graft dysfunction (40 vs 32%) but no increase in surgical complications. Both the post-operative FVC (2498mL/66% vs 2104mL/65%) and FEV1 (1735mL/57% vs 1619mL/56%) were improved in silicosis but not statistically significant. Conclusions: Although the number of pts is small, we demonstrated that in spite of the challenging surgical technique and worse operative conditions of LT in pts with silicosis, this group have a similar survival and perioperative complications after LT. |
| Databáze: | OpenAIRE |
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