Stereoselective synthesis of α-fluoroacrylonitriles via organocatalytic cyanation of gem-difluoroalkenes and TMSCN

Autor:	Yu-Chuan Ma, Yang Zhang, Cheng-Zhi Gu, Lin He, Guang-Fen Du
Rok vydání:	2019
Předmět:	chemistry.chemical_compound Nucleophile Chemistry Materials Chemistry Stereoselectivity General Chemistry Cyanation Selectivity Trimethylsilyl cyanide Medicinal chemistry Catalysis
Zdroj:	New Journal of Chemistry. 43:10985-10988
ISSN:	1369-9261 1144-0546
Popis:	An organocatalytic cyanation reaction of gem-difluoroalkenes was developed. Under the catalysis of 10 mol% DBU, gem-difluoroalkenes undergo a nucleophilic addition-β-elimination reaction with trimethylsilyl cyanide to provide α-fluoroacrylonitriles in 50–98% yields with excellent Z/E selectivity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b1a19008afe264cc7cb06027ae25503f https://doi.org/10.1039/c9nj02370d Zobrazit plný text záznamu