The physicochemical, safety and antimicrobial properties of Phyllanthus amarus herbal cream and ointment
| Autor: | Adebowale Bernard Saba, O.O. Aina, Oluwatoyin A. Odeku, MN Femi-Oyewo, Olayinka O. Oridupa, Tolulope O. Ajala |
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| Rok vydání: | 2015 |
| Předmět: |
biology
Traditional medicine 010405 organic chemistry business.industry Pharmaceutical Science Trichophyton rubrum Pharmacology Antimicrobial biology.organism_classification medicine.disease_cause Cetomacrogol 1000 01 natural sciences 0104 chemical sciences Humectant 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry Staphylococcus aureus Maceration (wine) Medicine Irritation skin and connective tissue diseases business Antibacterial activity Pharmacology Toxicology and Pharmaceutics (miscellaneous) |
| Zdroj: | Journal of Pharmaceutical Investigation. 46:169-178 |
| ISSN: | 2093-6214 2093-5552 |
| DOI: | 10.1007/s40005-015-0226-8 |
| Popis: | The ethanol extract of Phyllanthus amarus (Schum and Thonn), a plant of ethnomedicinal importance, was formulated into herbal cream and ointment and evaluated using physicochemical, safety and antimicrobial properties. The extract was obtained by maceration and the antimicrobial properties tested on clinically isolated pathogenic bacteria (Staphylococcus aureus and Pseudomonas aeruginosa) and dermatophytes (Trichophyton rubrum and Candida albicans) using established methods. Cream and ointment formulations containing 1–10 % w/w extract was prepared and 4 % w/w humectant (glycerin) was incorporated into the cream while 5 % w/w surfactant (cetomacrogol 1000) was incorporated to the ointment. The results showed that the pH of the formulations was acidic and the viscosity ranged from 1250 to 4950 cP for ointments and 570–1233 cP for creams. The presence of humectant and surfactant significantly (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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