| Autor: |
Maria K. Angelopoulou, Flora N. Kontopidou, Christos Karkantaris, Antonia Giannakakis, Christos Kittas, P Korkolopoulou, Eleni Variamis, Konstantinos Anargyrou, Styliani I. Kokoris, Panayiotis Tsaftaridis, Maria N. Dimopoulou, Dimitrios Boutsis, Marina P. Siakantaris, Theodoros P. Vassilakopoulos, Marie-Christine Kyrtsonis, John Rombos, Gerassimos A. Pangalis |
| Rok vydání: |
2002 |
| Předmět: |
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| Zdroj: |
European Journal of Haematology. 68:289-298 |
| ISSN: |
0902-4441 |
| DOI: |
10.1034/j.1600-0609.2002.01721.x |
| Popis: |
Objectives: To investigate the prognosis of patients with Hodgkin's lymphoma (HL) who relapse following a complete remission (CR) achieved by chemotherapy with or without radiotherapy (CT±RT), and to identify prognostic factors for freedom from second progression (FF 2 P). Methods: We analyzed the prognostic significance of the initial CT regimen (4 vs. 7-8 drugs), treatment-free interval (TFI), and demographic, clinical, and laboratory factors at the time of relapse and diagnosis, in 113 patients with HL, who relapsed after a CR achieved by CT±RT. Results: Conventional salvage CT±RT was administered in 107 patients, while six received RT only. The 5-yr FF 2 P was 24%, while the 10-yr survival after relapse (O 2 S) was 39% and was not afffected by the initial CT regimen. Multivariate analysis revealed that extranodal disease at relapse (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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