Thrombin generation in patients after acute deep-vein thrombosis

Autor:	Karly Hamulyák, Arina J. ten Cate-Hoek, Martin H. Prins, Rene van Oerle, Hugo ten Cate, Henri M. H. Spronk, Arne W. J. H. Dielis
Rok vydání:	2008
Předmět:	medicine.medical_specialty Pathology business.industry Vascular disease Deep vein Reference range Hematology medicine.disease Thrombomodulin Thrombosis Venous thrombosis medicine.anatomical_structure Thrombin Internal medicine medicine Cardiology Coagulopathy business medicine.drug
Zdroj:	Thrombosis and Haemostasis. 100:240-245
ISSN:	2567-689X 0340-6245
DOI:	10.1160/th08-02-0099
Popis:	SummaryThrombin generation measurement may be of value for assessing the risk of venous thromboembolism, but its long term profile has not been assessed in patients. We evaluated thrombin generation by Calibrated Automated Thrombogram (CAT) in plasma during follow up of 104 consecutive patients after an acute episode of deep venous thrombosis. Blood was drawn three times over the course of 24 months. Thrombin generation was measured in absence and presence of thrombomodulin and compared to a reference range derived from thrombin generation curves in 137 healthy volunteers. Thrombin generation of patients showed significantly higher endogenous thrombin potential (ETP) and peak height compared to the reference population. Differences were more pronounced in assays triggered with I pM TF. Inhibition by thrombomodulin was attenuated in patients off anticoagulants as compared to the reference population (21 % vs.42.2%, p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b17d86159137f12edae8ee76c741ded5 https://doi.org/10.1160/th08-02-0099 Zobrazit plný text záznamu