| Autor: |
Giulio Superti-Furga, Martin Senekowitsch, Mark J. Smyth, Michael Schuster, Thomas Penz, Franziska Michor, Franz Allerberger, Judith H. Aberle, Elisabeth Puchhammer-Stoeckl, Manfred Nairz, Wegene Borena, Mario Karolyi, Jakob-Wendelin Genger, Lukas Endler, Miguel L. Grau, Zsofia Keszei, Monika Redlberger-Fritz, Christoph Bock, Martin Borkovec, Dorothee von Laer, Henrique G. Colaço, Andreas Bergthaler, Michael T. Wolfinger, Michael D. Nicholson, Daniela Schmid, Erich Pawelka, Jan Laine, Benedikt Agerer, Alexander Zoufaly, Alexandra Popa, Stephan W. Aberle, Francisco Martinez Jimenez, Oriol Pich, Alexander Lercher, Guenter Weiss, Peter Hufnagl, Sabine Maritschnik, Nuria Lopez-Bigas |
| Rok vydání: |
2020 |
| Předmět: |
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| Popis: |
Superspreading events shape the COVID-19 pandemic. Here we provide a national-scale analysis of SARS-CoV-2 outbreaks in Austria, a country that played a major role for virus transmission across Europe and beyond. Capitalizing on a national epidemiological surveillance system, we performed deep whole-genome sequencing of virus isolates from 576 samples to cover major Austrian SARS-CoV-2 clusters. Our data chart a map of early viral spreading in Europe, including the path from low-frequency mutations to fixation. Detailed epidemiological surveys enabled us to calculate the effective SARS-CoV-2 population bottlenecks during transmission and unveil time-resolved intra-patient viral quasispecies dynamics. This study demonstrates the power of integrating deep viral genome sequencing and epidemiological data to better understand how SARS-CoV-2 spreads through populations.Graphical Abstract |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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