Replacing the tropolonic methoxyl group of colchicine with methylamino increases tubulin binding affinity with improved therapeutic index and overcomes paclitaxel cross-resistance
| Autor: | Juanjuan Yang, Dake Song, Bingqian Li, Xiaoxiao Gao, Yuetong Wang, Xiaohu Li, Changshun Bao, Caijiao Wu, Yu Bao, Samuel Waxman, Guoliang Chen, Yongkui Jing |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Drug Resistance Updates. 68:100951 |
| ISSN: | 1368-7646 |
| DOI: | 10.1016/j.drup.2023.100951 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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