Analysis of skin dose distribution for the prediction of severe radiation dermatitis in head and neck squamous cell carcinoma patients treated with concurrent chemo‐radiotherapy
| Autor: | Roberta De Majo, Cinzia Talamonti, Luciana Lastrucci, Andrea Rampini, Lorenzo Livi, Isacco Desideri, Luca Dominici, Assunta Simona Curion, Silvia Bertocci, Livia Marrazzo, Saverio Caini, Stefania Pallotta, Chiara Gasperi, D. Pezzulla, Pierluigi Bonomo |
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| Rok vydání: | 2019 |
| Předmět: |
Cisplatin
Cetuximab business.industry medicine.medical_treatment Incidence (epidemiology) Head and neck cancer medicine.disease Head and neck squamous-cell carcinoma 030218 nuclear medicine & medical imaging Radiation therapy 03 medical and health sciences symbols.namesake 0302 clinical medicine Otorhinolaryngology 030220 oncology & carcinogenesis Relative risk symbols Medicine Poisson regression business Nuclear medicine medicine.drug |
| Zdroj: | Head & Neck. 42:244-253 |
| ISSN: | 1097-0347 1043-3074 |
| Popis: | Background We investigated whether the pattern of intensity-modulated radiotherapy (IMRT) dose distribution to the skin can be correlated with the development of G3/G4 radiation dermatitis (RD). Methods A frequency-matched cohort analysis was perfomed on patients treated with IMRT and concurrent cisplatin or cetuximab. Risk ratios were obtained by fitting Poisson regression models. Results The incidence of G3/G4 RD was 41.1% in 90 patients included (50% vs 36.6% in the cetuximab and cisplatin cohorts, respectively). In multivariate analysis, PS ≥ 1 and weight loss at RT completion >10 kg were the only factors that retained significance. The best dosimetric predictive accuracy was provided by 19.9 cc and 5.8 cc of skin ring 2 mm V50 and V60, respectively (AUC: 0.61 for both). Conclusion Along with clinical factors, the pattern of dose distribution to a ring structure localized 2 mm below the patient's surface may help predict the development of severe RD. |
| Databáze: | OpenAIRE |
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