Treadmill exercise improves depression-like symptoms by enhancing serotonergic function through upregulation of 5-HT1A expression in the olfactory bulbectomized rats
| Autor: | Sangseo Park, Jae-Min Lee, Young-Pyo Kim, Tae-Woon Kim, Mal-Soon Shin |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Physical Therapy Sports Therapy and Rehabilitation 030229 sport sciences Tryptophan hydroxylase Serotonergic Open field 03 medical and health sciences 0302 clinical medicine Endocrinology Dorsal raphe nucleus Internal medicine medicine Orthopedics and Sports Medicine Serotonin Treadmill Psychology 030217 neurology & neurosurgery 5-HT receptor Behavioural despair test |
| Zdroj: | Journal of Exercise Rehabilitation. 13:36-42 |
| ISSN: | 2288-1778 2288-176X |
| DOI: | 10.12965/jer.1734918.459 |
| Popis: | The olfactory bulbectomy (OBX) is a well-known method inducing animal model of depression. Depression is associated with dysfunction of serotonin (5-hydroxytryptamine, 5-HT) system. In the present study, antidepressive effect of treadmill exercise was investigated using olfactory bulbectomized rats. After bilateral bulbectomy, the rats in the treadmill exercise groups were subjected to run on a treadmill for 30 min once a day during 28 days. Increased immobility time and decreased fast time in the forced swim test were observed in the olfactory bulbectomized rats. Sucrose preference in the sucrose preference test was decreased and activity in the open field test was also increased in the olfactory bulbectomized rats. Treadmill exercise decreased immobility time and activity and increased fast time and sucrose preference in the olfactory bulbectomized rats. Expressions of 5-HT and tryptophan hydroxylase (TPH) in the dorsal raphe of rats were suppressed by OBX and treadmill exercise increased the expressions of 5-HT and TPH in the olfactory bulbectomized rats. Serotonin receptor type 1A (5-HT1A) expression in the dorsal raphe was reduced by OBX and treadmill exercise increased 5-HT1A expression in the olfactory bulbectomized rats. In the present study, treadmill exercise ameliorated OBX-induced depressive symptoms. The antidepressive effect of treadmill exercise might be ascribed to the enhancement of serotonergic function through upregulation of 5-HT1A expression in the dorsal raphe. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|