Chemical and enzymatic synthesis of high-affinity selectin ligands
| Autor: | B. Hörsch, G. Kuznik, Carlo Unverzagt, G. Kretzschmar |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
chemistry.chemical_classification
biology Stereochemistry Organic Chemistry Clinical Biochemistry Aldolase A Pharmaceutical Science Fructose-bisphosphate aldolase Biochemistry Chemical synthesis Sialic acid carbohydrates (lipids) chemistry.chemical_compound Residue (chemistry) Enzyme chemistry Drug Discovery biology.protein Molecular Medicine Moiety Tetrasaccharide Molecular Biology |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 7:577-580 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/s0960-894x(97)00051-6 |
| Popis: | Analogs of sialyl LewisX have been synthesized chemically using donors of modified sialic acids. The sialic acids were obtained enzymatically by an aldolase reaction. The sLex tetrasaccharides modified at C-2 of the GlcNAc moiety and at C-5 of the sialic acid residue were tested as inhibitors for E- and P-selectins. Up to 12-fold higher inhibitory potency was found for the lyso-derivative of sLeX compared to the parent compound. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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