Parkinson's syndrome simulated by injection of kainic acid into the caudate nuclei

Autor:	G. N. Kryzhanovskii, R. F. Makul'kin, A. A. Shandra, L. S. Godlevskii, V. S. Rozhkov
Rok vydání:	1987
Předmět:	Kainic acid General Medicine Biology Rat brain General Biochemistry Genetics and Molecular Biology Synapse chemistry.chemical_compound nervous system chemistry Hypothalamus Ageing Ultrastructure Blue spot sense organs PARKINSON'S SYNDROME Neuroscience
Zdroj:	Bulletin of Experimental Biology and Medicine. 103:732-736
ISSN:	1573-8221 0007-4888
DOI:	10.1007/bf00842320
Popis:	Electron microscopy was used to study structural changes of synapses in sensorimotor, parietal, limbic cortical areas, hippocamp, blue spot and hypothalamus of old Wistar rats, aged 28-30 months. Polymorphism of ultrastructural changes in neuronal and synapse processes and individual variability of these shifts in the brain of old rats have been revealed. The predominant damage of post-synaptic synapse components with ageing is demonstrated. Along with dystrophic and destructive changes in pre- and post-synaptic parts of the contact, signs of compensatory adaptive resettings in inter-neuronal links have been detected.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b1664796010acbcf50c115cb577ff25f https://doi.org/10.1007/bf00842320 Zobrazit plný text záznamu Full text from SpringerLink