Positive contrast with alternating repetition time SSFP (PARTS): A fast imaging technique for SPIO-labeled cells
| Autor: | William R. Overall, Tolga Çukur, Phillip C. Yang, Dwight G. Nishimura, Mayumi Yamada |
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| Rok vydání: | 2010 |
| Předmět: |
Materials science
medicine.diagnostic_test media_common.quotation_subject Magnetic resonance imaging Steady-state free precession imaging Image enhancement Nuclear magnetic resonance Positive contrast Repetition Time Background suppression medicine Contrast (vision) Radiology Nuclear Medicine and imaging Imaging technique media_common |
| Zdroj: | Magnetic Resonance in Medicine. 63:427-437 |
| ISSN: | 0740-3194 |
| DOI: | 10.1002/mrm.22241 |
| Popis: | There has been recent interest in positive-contrast MRI methods for noninvasive tracking of cells labeled with superparamagnetic iron-oxide (SPIO) nanoparticles. Low-tip-angle balanced steady-state free precession (bSSFP) sequences have been used for fast, high-resolution, and flow-insensitive positive-contrast imaging; however, the contrast can be compromised by the limited suppression of the on-resonant and fat signals. In this work, a new technique that produces positive contrast with alternating repetition time SSFP (PARTS) is proposed to achieve robust background suppression for a broad range of tissue parameters. In vitro and in vivo experiments demonstrate the reliability of the generated positive contrast. The results indicate that PARTS can enhance the suppression level by up to 18 dB compared with conventional bSSFP. |
| Databáze: | OpenAIRE |
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