Early Vascular Healing Following Bioresorbable-Polymer Sirolimus-Eluting Stent Placement Compared to That with Durable-Polymer Everolimus-Eluting Stent
| Autor: | Koshiro Sakai, Ryota Masaki, Myong Hwa Yamamoto, Yosuke Oishi, Shunya Sato, Hiroshi Suzuki, Toshiro Shinke, Ken Arai, Masahiko Ochiai, Rikuo Sakai, Kosuke Nomura, Kohei Wakabayashi, Kunihiro Ogura, Hiroaki Tsujita, Teruo Sekimoto, Ryota Kosaki, Hidenari Matsumoto, Taito Arai, Shigeto Tsukamoto, Naoki Matsukawa, Seita Kondo, Hideaki Tanaka, Hiroyoshi Mori |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
business.industry
medicine.medical_treatment Everolimus eluting stent Stent Percutaneous coronary intervention General Medicine equipment and supplies Vascular healing Stent placement surgical procedures operative Drug-eluting stent Sirolimus Conventional PCI Medicine cardiovascular diseases Cardiology and Cardiovascular Medicine business Nuclear medicine medicine.drug |
| Zdroj: | International Heart Journal. 62:510-519 |
| ISSN: | 1349-3299 1349-2365 |
| Popis: | A recent thinner strut drug-eluting stent might facilitate early strut coverage after its placement. We aimed to investigate early vascular healing responses after the placement of an ultrathin-strut bioresorbable-polymer sirolimus-eluting stent (BP-SES) compared to those with a durable-polymer everolimus-eluting stent (DP-EES) using optical coherence tomography (OCT) imaging.This study included 40 patients with chronic coronary syndrome (CCS) who underwent OCT-guided percutaneous coronary intervention (PCI). Twenty patients each received either BP-SES or DP-EES implantation. OCT was performed immediately after stent placement (baseline) and at 1-month follow-up.At one month, the percentage of uncovered struts reduced significantly in both the BP-SES (80.9 ± 10.3% to 2.9 ± 1.7%; P < 0.001) and DP-EES (81.9 ± 13.0% to 5.7 ± 1.8%; P < 0.001) groups, and the percentage was lower in the BP-SES group than in the DP-EES group (P < 0.001). In the BP-SES group, the percentage of malapposed struts also decreased significantly at 1 month (4.9 ± 3.7% to 2.6 ± 3.0%; P = 0.025), which was comparable to that of the DP-EES group (2.5 ± 2.2%; P = 0.860). The optimal cut-off value of the distance between the strut and vessel surface immediately after the placement to predict resolved malapposed struts was ≤ 160 μm for BP-SES and ≤ 190 μm for DP-EES.Compared to DP-EES, ultrathin-strut BP-SES demonstrated favorable vascular responses at one month, with a lower rate of uncovered struts and a comparable rate of malapposed struts. |
| Databáze: | OpenAIRE |
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