| Autor: |
Per Ludvik Brattås, Jenny Johansson, Daniela A. Grassi, Didier Trono, Diahann A. M. Atacho, Johan Jakobsson, Yogita Sharma, Julien Pontis, Raquel Garza, Karolina Pircs, Pia A. Johansson, PingHsun Hsieh, Marie E. Jönsson, Christopher H. Douse, Feride Eren, Evan E. Eichler |
| Rok vydání: |
2020 |
| Předmět: |
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| DOI: |
10.1101/2020.08.18.255562 |
| Popis: |
The human forebrain has expanded in size and complexity compared to that of chimpanzee despite limited changes in protein-coding genes, suggesting that gene regulation is an important driver of brain evolution. Here we identify a KRAB-ZFP transcription factor, ZNF558, that is expressed in human but not chimpanzee forebrain neural progenitor cells. ZNF558 evolved as a suppressor of LINE-1 transposons but has been co-opted to regulate the mitophagy gene SPATA18, supporting a link between mitochondrial homeostasis and cortical expansion. The unusual on-off switch for ZNF558 expression resides in a downstream variable number tandem repeat (VNTR) that is contracted in humans relative to chimpanzee. Our data reveal the brain-specific co-option of a transposon-controlling KRAB-ZFP and how a human-specific regulatory network is established by a cis-acting structural genome variation. This represents a previously undescribed genetic mechanism in the evolution of the human brain. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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