| Autor: |
Filiz Yesilkoy, Alexander Belushkin, Hatice Altug |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVII. |
| DOI: |
10.1117/12.2545619 |
| Popis: |
We present a nanoparticle (NP) enhanced imaging-based plasmonic biosensing technique using gold nanohole arrays (Au-NHAs) that enables highly sensitive protein detection with single analyte resolution in a one-step sandwich immunoassay. By digital quantification of individual Au-NP bound molecules on large area plasmonic surface, the portable biosensor enables rapid and robust detection of disease biomarkers from patient serum in hospital settings. Using mass-scalable deep-UV lithography (DUVL) sensor fabrication and simple LED based imaging set-up in a microarray format, our novel technology provides a powerful tool for clinical biomarker detection in a highly multiplexed manner. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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