Recyclization of 1,3-dialkyl-6-nitro-1H-imidazo[4,5-b]pyridine-2,5(3H,4H)-diones into imidazole derivatives

Autor:	D. A. Lomov
Rok vydání:	2016
Předmět:	Aqueous solution 010405 organic chemistry Organic Chemistry Hydrazine Potassium nitrate 010402 general chemistry 01 natural sciences Medicinal chemistry 0104 chemical sciences chemistry.chemical_compound chemistry Pyridine Nitro Imidazole Organic chemistry Sodium nitrite Hydrate
Zdroj:	Russian Journal of Organic Chemistry. 52:51-53
ISSN:	1608-3393 1070-4280
DOI:	10.1134/s1070428016010103
Popis:	Treatment of 5-amino-1,3-dialkyl-2,3-dihydro-1H-imidazo[4,5-b]pyridin-2-ones with sodium nitrite in aqueous HCl gave 1,3-dialkyl-1H-imidazo[4,5-b]pyridine-2,5(3H,4H)-diones which were nitrated with potassium nitrate in sulfuric acid to 6-nitro derivatives, and the latter underwent recyclization into 4-amino-1,3-dialkyl-5-(1H-pyrazol-5-yl)-2,3-dihydro-1H-imidazol-2-ones by the action of hydrazine hydrate.
Databáze:	OpenAIRE
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